Global Research Lab

We aim to visualize the dynamic progressions of ensemble DNA mismatch repair (MMR) in vitro and in vivo to detail the mechanism of MMR using single-molecule techniques, and then develop a platform to screen MMR functions of a single cell at the single-molecule level, which will make it possible to overcome the heterogeneity problem of cancer cells for precision medicine. This research is supported by Global Research Lab Program through the National Research Foundation of Korea Funded by the Ministry of Science & ICT.

PI: Prof. Jong-Bong Lee
Foreign PI: Prof. Richard Fishel (Ohio State University)
Partner Investigator: Prof. Jae-Hyung Jeon (POSTECH)